Intern
    Onkologische Forschung

    Andreas Beilhack:
    Experimental Stem Cell Transplantation

    Summary

    Our group investigates how the immune system distinguishes between friend and foe. We focus on dynamic immune cell interactions after allogeneic hematopoietic cell transplantation, an often curative but also risk-associated therapy for many malignancies. In preclinical models we explore anti-tumor mechanisms, graft-versus-host disease and graft-versus-infection mechanisms exerted by allogeneic immune cell subpopulations. To gain better insights into these complex immune processes we employ state-of-the-art imaging techniques with the ultimate goal to translate our findings into improved diagnostics and therapies.

    Recent Publications

    Chopra M, Brandl A, Siegmund D, Mottok A, Schäfer V, Biehl M, Kraus S, Bäuerlein CA, Ritz M, Mattenheimer K, Schwinn S, Seher A, Grabinger T, Einsele H, Rosenwald A, Brunner T, Beilhack A*, Wajant H*. (2015). Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GvHD.
    Blood
    126(4):437-444. *Equal contribution and co-corresponding author.

    Editorial: Blood 126(4):429-30.

    Kim BS, Nishikii H, Baker J, Pierini A, Schneidawind A, Pan Y, Beilhack A, Park CG, Negrin RS. (2015). Treatment with Agonistic DR3 Antibody Results in Expansion of Donor Tregs and Reduced Acute Graft-versus-Host Disease. Blood 126(4):546-557

    Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T. (2015). Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nature Immunology 16(3): 267-275.

    Meinhardt K, Kroeger I, Bauer R, Ganss F, Ovsiy I, Rothamer J, Büttner M, Atreya I, Waldner M, Bittrich M, Lehmann CHK, Rieger MA, Beilhack A, Zeiser R, Edinger M, Dudziak D, Mackensen A, Rehli M, Ullrich E. (2015). Identification and characterization of the specific murine NK cell subset supporting graft-versus-leukemia- and reducing graft-versus-host- effects. Oncoimmunology 4:1, e981483.

    Vaeth M, Bäuerlein CA, Pusch T, Findeis J, Chopra M, Mottok A, Rosenwald A., Beilhack A, Berberich-Siebelt F. (2015). Selective NFAT targeting in T cells ameliorates GvHD while maintaining anti-tumor activity. Proc Natl Acad Sci USA 112(4): 1125-1130.

    Kontakt

    Comprehensive Cancer Center
    Haus C16
    Josef-Schneider Str. 6
    97080 Würzburg

    Tel.: +49 931 201-35350
    Fax: +49 931 201-35359
    E-Mail

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