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Intern
    Onkologische Forschung

    Martin Eilers: Cell Proliferation

    Summary

    Our group is interested in how cell proliferation and cell growth are deregulated in human tumors. We focus our studies on the Myc gene family: those are proto-oncogenes that drive the growth of many human tumors. They encode transcription factors that regulate genes involved in cell proliferation, cell growth and metabolism. Our group studies the function of new proteins and tries to find ways to target them for tumor therapy.

    Recent Publications 

    Herold, S., Kalb, J., Buchel, G., Ade, C. P., Baluapuri, A., Xu, J., Koster, J., Solvie, D., Carstensen, A., Klotz, C., Rodewald, S., Schulein-Volk, C., Dobbelstein, M., Wolf, E., Molenaar, J., Versteeg, R., Walz, S., Eilers, M. (2019). Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA Polymerase. Nature. Mar 20. doi:10.1038/s41586-019-1030-9. PubMed PMID: 30894746.

    Baluapuri, A., Hofstetter, J., Dudvarski Stankovic, N., Endres, T., Bhandare, P., Vos, S.M., Adhikari, B., Schwarz, J.D., Narain, A., Vogt, M., Wang, S.Y., Düster, R., Jung, L.A., Vanselow, J.T., Wiegering, A., Geyer, M., Maric, H.M., Gallant, P., Walz, S., Schlosser, A., Cramer, P., Eilers, M., Wolf, E. (2019) MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Molecular Cell Mar 21 pii:S1097-2765(19)30142-X. doi: 10.1016/j.molcel.2019.02.031. PubMed PMID: 30928206.

    Büchel, G., Carstensen, A., Mak, K.Y., Roeschert, I., Leen, E., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., Poon, E., Kwok, C., Chesler, L., Maric H. M., Rickman, D. S., Wolf, E., Bayliss, R., Walz, S., Eilers, M. (2017) Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during cell cycle. Cell Reports Dec 19;21(12):3483-3497. doi:10.1016/j.celrep.2017.11.090.

    von Eyss, B., Jaenicke, L.A., Kortlever, R.M., Royla, N., Wiese, K.E., Letschert, L., McDuffus, L.A., Sauer, M., Rosenwald, A., Evan, G.I., Kempa, S., and Eilers, M. (2015) A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer. Cancer Cell, 28:743-57.

    Walz, S., Lorenzin, F., Morton, J., Wiese, K.E., von Eyss, B., Herold, S., Rycak, L., Dumay-Odelot, H., Karim, S., Bartkuhn, M., Roels, F., Wuestefeld, T., Fischer, M., Teichmann, M., Zender, L., Wei, C. L., Sansom, O., Wolf, E., and Eilers, M. (2014) Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles. Nature 511: 483-487.