Our group investigates the pathways that control animal growth, both under physiological and under pathological conditions. We are particularly interested in the transcription factor and proto-oncogene Myc, its transcriptional targets and the molecular mechanism by which they are controlled. We use Drosophila melanogaster as a model system for these studies, and also to investigate additional signals that coordinate animal growth during development.
Herter, E.K., Stauch, M., Gallant, M., Wolf, E., Raabe, T., and Gallant, P. (2015). snoRNAs are a novel class of biologically relevant Myc targets. BMC Biology 13, 25.
Hovhanyan, A., Herter, E.K., Pfannstiel, J., Gallant, P., and Raabe, T. (2014). Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts. Mol. Cell. Biol. 34, 1878-1891.
Gallant, P. (2013). Myc Function in Drosophila. Cold Spring Harb Perspect Med 3 (10), a014324; doi: 10.1101/cshperspect.a014324.
Furrer, M., Balbi, M., Albarca-Aguilera, M., Gallant, M., Herr, W. and Gallant., P. (2010) Drosophila Myc interacts with Host Cell Factor (dHCF) to activate transcription and control growth. J. Biol. Chem. 285, 39623-39636.
Steiger, D., Furrer, M., Schwinkendorf, D. and Gallant, P. (2008). Max-independent functions of Myc in Drosophila melanogaster. Nature Genetics 40, 1084-1091.