Our group is interested in tumor modifier genes, genes that are not involved in the primary processes of neoplastic transformation like oncogenes and tumor suppressor genes but which determine the course of the disease. We use established small laboratory fish models for melanoma to identify and characterize such modifier genes and then evaluate their function in comparative studies in the fish models and in human melanoma biopsies and cell lines.
Kneitz S., Mishra R., Chalopin D., Postlethwait J., Warren W., Walter R., Schartl M. (2016) Germ cell and tumor associated piRNAs in medaka and Xiphophorus melanoma models. BMC Genomics 17, 357
Schartl M, Shen Y, Maurus K, Walter R, Wilson RK, Postlethewait J, Warren WC. (2015) Whole body melanoma transcriptome response in medaka. Plos One 10: e0143057
Liedtke D., Erhard I., Abe K., Furutani-Seiki M., Kondoh H., Schartl M. (2014) Xmrk-induced melanoma progression is affected by Sdf1 signals through Cxcr7. Pigment cell & melanoma research 27, 221-233
Haydn JM, Hufnagel A, Grimm J, Maurus K, Schartl M & Meierjohann S. (2014) The MAPK pathway as an apoptosis enhancer in melanoma. Oncotarget 5, 5040-5053
Schartl M, Walter RB, Shen Y, Garcia T, Catchen J, Amores A, Braasch I, Chalopin D, Volff JN, Lesch KP, Bisazza A, Minx P, Hillier L, Wilson RK, Fuerstenberg S, Boore J, Searle S, Postlethwait JH & Warren WC. (2013) The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits. Nat Genet 45, 567-572