Onkologische Forschung

    Almut Schulze: Cancer Metabolism


    Our group is interested in the deregulation of cellular metabolic activity that is found in human tumors. Alterations in metabolic activity support the proliferation of cancer cells and are crucial for cancer development. Our work aims to understand the mechanisms that lead to metabolic changes in cancer cells and to identify specific metabolic processes that could be targeted for cancer therapy.

    Recent Publications

    Ros, S., Flöter, J., Kaymak, I., Da Costa, C., Houddane, A., Dubuis, S., Griffiths, B., Mitter, R., Walz, S., Blake, S., Behrens, A., Brindle, KM., Zamboni, N., Rider, M.H. and Schulze, A., (2017) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells, Oncogene, doi: 10.1038/onc.2016.477

    Rohrig, F., and Schulze, A. (2016). The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer.

    Peck, B., Schug, Z.T., Zhang, Q., Dankworth, B., Jones, D.T., Smethurst, E., Patel, R., Mason, S., Jiang, M., Saunders, R., Howell, M., Mitter, R., Spencer-Dene, B., Stamp, G., McGarry, L., James, D., Shanks, E., Aboagye, E.O., Critchlow, S.E., Leung, H.Y., Harris, A.L., Wakelam, M.J., Gottlieb, E., and Schulze, A. (2016). Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 4, 6.

    Schug, Z.T.*, Peck, B.*, Jones, D.T., Zhang, Q., Grosskurth, S., Alam, I.S., Goodwin, L.M., Smethurst, E., Mason, S., Blyth, K., McGarry, L., James, D., Shanks, E., Kalna, G., Saunders, B., Jiang, M., Howell, M., Lassailly, F., Zaw Thin, M., Spencer-Dene, B., Stamp, G., van den Broek, N., Mackay, G., Bulusu, V., Kamphorst, J.J., Tardito, S., Strachan, D., Harris, A.L., Aboagye, E.O., Critchlow, S.E., Wakelam, M.J.O., Schulze, A. and Gottlieb, E. (2015) Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth Under Metabolic Stress. Cancer Cell 27: 57-71, *equal contribution

    Ros, S.*, Santos, C.R.*, Moço, S., Baenke, F., Kelly, G., Howell, M., Zamboni, N. and Schulze, A. (2012) Functional screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB4) as an important regulator of prostate cancer cell survival. Cancer Discovery 2:328-343, *equal contribution


    Comprehensive Cancer Center Mainfranken
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