Intern
    Onkologische Forschung

    Manfred Schartl: Tumor genetics

    Summary

    Our group is interested in tumor modifier genes, genes that are not involved in the primary processes of neoplastic transformation like oncogenes and tumor suppressor genes but which determine the course of the disease. We use established small laboratory fish models for melanoma to identify and characterize such modifier genes and then evaluate their function in comparative studies in the fish models and in human melanoma biopsies and cell lines.

    Recent Publications

    Kneitz S., Mishra R., Chalopin D., Postlethwait J., Warren W., Walter R., Schartl M. (2016) Germ cell and tumor associated piRNAs in medaka and Xiphophorus melanoma models. BMC Genomics 17, 357

    Schartl M, Shen Y, Maurus K, Walter R, Wilson RK, Postlethewait J, Warren WC. (2015) Whole body melanoma transcriptome response in medaka. Plos One 10: e0143057

    Liedtke D., Erhard I., Abe K., Furutani-Seiki M., Kondoh H., Schartl M. (2014) Xmrk-induced melanoma progression is affected by Sdf1 signals through Cxcr7. Pigment cell & melanoma research 27, 221-233

    Haydn JM, Hufnagel A, Grimm J, Maurus K, Schartl M & Meierjohann S. (2014) The MAPK pathway as an apoptosis enhancer in melanoma. Oncotarget 5, 5040-5053

    Schartl M, Walter RB, Shen Y, Garcia T, Catchen J, Amores A, Braasch I, Chalopin D, Volff JN, Lesch KP, Bisazza A, Minx P, Hillier L, Wilson RK, Fuerstenberg S, Boore J, Searle S, Postlethwait JH & Warren WC. (2013) The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits. Nat Genet 45, 567-572

    Kontakt

    Comprehensive Cancer Center
    Haus C16
    Josef-Schneider Str. 6
    97080 Würzburg

    Tel.: +49 931 201-35350
    Fax: +49 931 201-35359
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