Nikita Popov: Ubiquitin signaling in cancer
Our group studies the role of the ubiquitin system in tumorigenesis. We elucidate basic ubiquitin-dependent mechanisms in transcription and DNA damage response and analyze how these mechanisms are altered during tumor development. We aim to understand how such cancer-associated changes contribute to tumor development and how they alter response to cancer treatments with the focus on ionizing radiation. Our ultimate goal is to exploit this knowledge to design efficient therapeutic strategies for human cancer.
Schuelein, C., Eilers, M., Popov, N. (2011) PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity. FEBS Letters, 585, 2151 – 7
Popov, N., Schülein, C., Jaenicke, L. and Eilers, M. (2010) Ubiquitination of the Myc amino-terminus by beta-TrCP antagonizes Fbw7-mediated degradation. Nature Cell Biology, 12, 973 – 81.
Popov, N., Wanzel, M., Madiredjo, M., Zhang, D., Beijersbergen, R., Bernards, R., Moll, R., Elledge, S.J., Eilers, M. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology, 9, 765 – 74.