Intern
    Onkologische Forschung

    Nikita Popov: Ubiquitin signaling in cancer

    Summary

    Our group studies the role of the ubiquitin system in tumorigenesis. We elucidate basic ubiquitin-dependent mechanisms in transcription and DNA damage response and analyze how these mechanisms are altered during tumor development. We aim to understand how such cancer-associated changes contribute to tumor development and how they alter response to cancer treatments with the focus on ionizing radiation. Our ultimate goal is to exploit this knowledge to design efficient therapeutic strategies for human cancer.

    Recent Publications

    Schuelein, C., Eilers, M., Popov, N. (2011) PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity. FEBS Letters, 585, 2151 – 7

    Popov, N., Schülein, C., Jaenicke, L. and Eilers, M. (2010) Ubiquitination of the Myc amino-terminus by beta-TrCP antagonizes Fbw7-mediated degradation. Nature Cell Biology, 12, 973 – 81.

    Popov, N., Wanzel, M., Madiredjo, M., Zhang, D., Beijersbergen, R., Bernards, R., Moll, R., Elledge, S.J., Eilers, M. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology, 9, 765 – 74.

    Kontakt

    Comprehensive Cancer Center
    Haus C16
    Josef-Schneider Str. 6
    97080 Würzburg

    Tel.: +49 931 201-35350
    Fax: +49 931 201-35359
    E-Mail

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