Intern
    Onkologische Forschung

    Andreas Schirbel: Theranostics

    Our group aims to establish theranostic concepts for personalized radionuclide therapy. We already established several theranostic pairs:

    1. [68Ga/177Lu]DOTATOC targeting neuroendocrine tumours

    2. [68Ga/177Lu]PSMA I&T targeting prostate carcinoma

    3. [68Ga/177Lu/90Y]CXCR4 targeting chemokine expressing tumours

    4. [123/131I]Iodometomidate targeting adrenocortical carcinoma

    5. [123/131I]IMAZA targeting adrenocortical carcinoma

    All therapies provide efficacious treatment and only few adverse effects are observed. The preparation of clinical trials and the development of further theranostic pairs is subject of our ongoing research.

    Recent Publications

    Philipp-Abbrederis K., Herrmann K., Knop K., Schottelius M., Eiber M., Pietschmann E., Gerngroß C, Lückerath K., Franke K., Rudelius M., Schirbel A., Lapa C., Götze K., Schwamborn K., Steidle S., Rosenwald A., Kropf S., Beer A.J., Peschel C., Einsele H., Buck A.K., Schwaiger M., Wester H.J., Keller U.; In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma. EMBO Mol. Med. 7 (2015) 477-487.

    Kreissl M.C., Schirbel A., Fassnacht M., Haenscheid H., Verburg F.A., Bock S., Saeger W., Knoedler P., Reiners C., Buck A.K., Allolio B., Hahner S. (2013), [123I]Iodometomidate Imaging in Adrenocortical Carcinoma. J. Clin. Endocrinol. Metab. 98, 2755-2764.

    Hahner S., Kreissl M.C., Fassnacht M., Haenscheid H., Bock S., Verburg F.A., Knoedler P., Lang K., Reiners C., Buck A.K., Allolio B., Schirbel A. (2013). Functional Characterization of Adrenal Lesions Using [123I]IMTO-SPECT/CT. J. Clin. Endocrinol. Metab. 98, 1508-1518.

    Hahner S., Kreissl M.C., Fassnacht M., Haenscheid H., Knoedler P., Lang K., Buck A.K., Reiners C., Allolio B., Schirbel A. (2012). [131I]Iodometomidate for Targeted Radionuclide Therapy of Advanced Adrenocortical Carcinoma. J. Clin. Endocrinol. Metab. 97, 914-922.

    Hahner S., Stuermer A., Kreissl M., Reiners C., Fassnacht M., Haenscheid H., Beuschlein F., Zink M., Lang K., Allolio B., Schirbel A. (2008). [123I]Iodometomidate for Molecular Imaging of Adrenocortical Cytochrome P450 Family 11B Enzymes. J. Clin. Endocrinol. Metab. 93, 2358-2365.

    Kontakt

    Comprehensive Cancer Center
    Haus C16
    Josef-Schneider Str. 6
    97080 Würzburg

    Tel.: +49 931 201-35350
    Fax: +49 931 201-35359
    E-Mail

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